@article{APS6095,
author = {Chang-hai DING and Wei WEI and Shu-yun XU},
title = {Effects of pineal body and melatonin on lymphocyte proliferation and dinoprostone production in rat spleen},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To determine the effects of pineal body and melatonin (Mel) on lymphocyte proliferation and dinoprostone production in rat spleen.
METHODS: Pinealectomy (PE), lymphocyte proliferation assay and dinoprostone radioimmunoassay were used.
RESULTS: A circadian rhythm of splenic lymphocyte proliferation which peaked at 22:00 was obliterated by PE in rats. PE led to an impairment of lymphocyte proliferation and an increase of dinoprostone production, which were restored by ip Mel 10 micrograms.kg-1.d-1 at 16:00 for 7 d. Mel promoted lymphocyte proliferation and inhibited dinoprostone production in intact rats. A negative correlation between the change in lymphocyte proliferation and dinoprostone production was seen.
CONCLUSION: The pineal body and its main hormone Mel play a regulatory role in circadian lymphocyte proliferation which is related to dinoprostone production in rat spleen.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6095}
}