@article{APS6082,
author = {Zhi-qi XIONG and Xi-can TANG and Jin-lai LIN and Da-yuan ZHU},
title = {Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of isovanihuperzine A (IVHA) on cholinesterase and scopolamine-induced memory deficit.
METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The Ki value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, rats were trained to perform a radial arm maze task using a partially baited procedure.
RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A), and was more potent than those of physostigmine and galanthamine with an IC50 value of 0.11 mumol.L-1. IVHA was a mixed competitive type with a Ki value of 32 nmol.L-1. It bound to AChE in a reversible manner. IVHA at a dose of 0.2 mg.kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze.
CONCLUSION: IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6082}
}