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Effect of dimethyl sulfoxide on cytosolic calcium in cultured rat hepatocytes injured by D-galactosamine

   
@article{APS6055,
	author = {Hua-Ping Liu and Zheng Cong},
	title = {Effect of dimethyl sulfoxide on cytosolic calcium in cultured rat hepatocytes injured by D-galactosamine},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {D-galactosamine (Gal 0.5 mmol.L-1) made lactate dehydrogenase (LDH) leakage from the hepatocytes in monolayer-culture increase by 50%, Dimethyl sulfoxide (Me2SO 2% vol/vol) decreased the LDH leakage (P less than 0.05). The cytosolic free Ca2+ concentration ([Ca2+]c) of rat hepatocytes exposed to Gal 4 mmol.L-1 for 90 min in suspension culture increased about 2-fold (P less than 0.01). Me2SO (2%) antagonized this [Ca2+]c-increasing effect of Gal. These results verified directly that the [Ca2+]c of hepatocytes was increased in the early stage of Gal-induced hepatotoxicity, and suggested that the prevention or lightening of the disturbance in intracellular Ca2+ homeostasis may be, at least, one of the mechanisms of the protective action of Me2SO against Gal-induced hepatocyte injury.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6055}
}