@article{APS6054,
author = {Li-jian Yu and Run-di Ma and Shi-bo Jiang},
title = {Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {2},
year = {2016},
keywords = {},
abstract = {Tubeimoside-1 (Tub) is a triterpenoid saponin first isolated in China from Bolbostemma paniculatum (Maxim) Franquet, Cucurbitaceae. To find out whether Tub has any anti-infective activity on human immunodeficiency virus (HIV), we tested its effects on HIV core protein p24 (with an ELISA) and HIV-mediated cytopathogenesis (using a colorimetric assay). The results showed that Tub inhibited both p24 production and cytopathogenesis mediated by HTLV-IIIB, and the median effective concentrations (EC50) were 24.1 and 22.9 micrograms.ml-1, respectively. Tub also effectively neutralized the infection of 2 other isolates, HTLV-IIIRF and HTLV-IIIMN. It is concluded that Tub had an inhibitory action on the infection of HIV-1 isolates and would be a promising candidate for treatment of AIDS},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6054}
}