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Rate- and voltage-dependent effects of m-nisoldipine on action potential of partially depolarized guinea pig papillary muscle

  
@article{APS6045,
	author = {Rui-Hai An and Rui-Rong He},
	title = {Rate- and voltage-dependent effects of m-nisoldipine on action potential of partially depolarized guinea pig papillary muscle},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The rate- and voltage-dependent effects of m-Nis were studied using standard microelectrode technique and real-time microcomputer analyzing system. The onset rate for rate-dependent inhibition (RDI) on action potentials of partially depolarized papillary muscle of guinea pig was accelerated as the concentration of m-Nis was increased from 0.5 to 2 mumol.L-1 or the driving frequency decreased from 0.8 to 0.2 Hz. The steady-state values of Vmax and APA were markedly decreased by elevating the concentration of m-Nis or increasing the driving frequency. The recovery time constants of Vmax, APA, and latency period from RDI were all increased by m-Nis (1 mumol.L-1). The inhibitory effects of m-Nis on Vmax and APA were more pronounced as the resting membrane potential was decreased by elevating K+ concentration in the perfusate.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6045}
}