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Pharmacokinetics of harringtonine liposomes in rabbits

  
@article{APS6039,
	author = {Huai-liang Wu and Guo-ying Weng and Zhao-hui Wu and You-cai Lu},
	title = {Pharmacokinetics of harringtonine liposomes in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {After i.v. free harringtonine (FH) and harringtonine liposomes (HL) with high and low encapsulation percentage (En%) to rabbits, their blood concentrations were determined by reverse-phase HPLC. The blood concentration-time curves were shown to fit a two-compartments open model. FH: T1/2 alpha = 1.32 +/- 0.24, T1/2 beta = 32 +/- 6 min; Low En % HL: T1/2 alpha = 4.12 +/- 0.25, T1/2 beta = 106 +/- 5 min; High En % HL: T1/2 alpha = 9.4 +/- 1.2, T1/2 beta = 209 +/- 5 min},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6039}
}