@article{APS6039,
author = {Huai-liang Wu and Guo-ying Weng and Zhao-hui Wu and You-cai Lu},
title = {Pharmacokinetics of harringtonine liposomes in rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {1},
year = {2016},
keywords = {},
abstract = {After i.v. free harringtonine (FH) and harringtonine liposomes (HL) with high and low encapsulation percentage (En%) to rabbits, their blood concentrations were determined by reverse-phase HPLC. The blood concentration-time curves were shown to fit a two-compartments open model. FH: T1/2 alpha = 1.32 +/- 0.24, T1/2 beta = 32 +/- 6 min; Low En % HL: T1/2 alpha = 4.12 +/- 0.25, T1/2 beta = 106 +/- 5 min; High En % HL: T1/2 alpha = 9.4 +/- 1.2, T1/2 beta = 209 +/- 5 min},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6039}
}