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Sodium ferulate alleviated paracetamol-induced liver toxicity in mice

   
@article{APS6038,
	author = {Hui Wang and Ren-xiu Peng},
	title = {Sodium ferulate alleviated paracetamol-induced liver toxicity in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Sodium ferulate (SF) is one of the effective components of Angelica sinensis Diels. Pretreatment with SF (100 mg.kg-1 ig, qd x 10 d) inhibited the activity of serum alanine aminotransferase, prevented the depletion of liver glycogen and glutathione, increased the liver homogenate and microsomal glutathione S-transferase activities, and reduced the malondialdehyde content, the membrane fluidity of liver microsome and the mitochondria in paracetamol (130 mg.kg-1, ip)-induced liver toxicity in mice. These results demonstrated the hepato-protective action of SF in mice},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6038}
}