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Pharmacokinetics and relative bioavailability of ofloxacin tablets in 12 healthy volunteers

   
@article{APS6037,
	author = {Yong Diao and Liang Li and Guo-Hua Zhou and Ying Cheng},
	title = {Pharmacokinetics and relative bioavailability of ofloxacin tablets in 12 healthy volunteers},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Single oral dose of tablet A (Daiichi Pharmaceutical Co Ltd, Japan) and B (Jining Pharmaceutical Factory, Shandong, China) of 300 mg ofloxacin (Ofl) were given to 12 Chinese healthy male volunteers in an open, randomized crossover study. Drug concentrations in serum and urine were assayed by HPLC and partial least squares spectrophotometric method, respectively. The serum concentration-time course after medication conformed to a 2-compartment open model with a first order absorption. Pharmacokinetic parameters after tablet B did not differ significantly from the corresponding values after tablet A. The bioavailability of tablet B was comparable to that of tablet A.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6037}
}