@article{APS6030,
author = {Dian-wen Ju and Qin-yue Zheng and Hong-bin Wang and Jun Fang},
title = {Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {1},
year = {2016},
keywords = {},
abstract = {Effects of triazolodiazepine (Tri) on mouse splenocyte proliferation and macrophage phagocytosis were studied. Tri 0.1-10 mumol.L-1 significantly inhibited concanavalin A (Con A) 5 micrograms.ml-1 and lipopolysaccharides (LPS) 10 micrograms.ml-1-induced splenocyte proliferation and phagocytic activity of activated peritoneal macrophages. Tri 10 mumol.L-1 reduced Con A-induced colony stimulating factor release from mouse splenocytes and LPS-challenged intracellular and extracellular interleukin-1 production from peritoneal macrophages. These results partially explain the wide and strong anti-inflammatory effects of Tri.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6030}
}