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Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro

  
@article{APS6030,
	author = {Dian-wen Ju and Qin-yue Zheng and Hong-bin Wang and Jun Fang},
	title = {Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Effects of triazolodiazepine (Tri) on mouse splenocyte proliferation and macrophage phagocytosis were studied. Tri 0.1-10 mumol.L-1 significantly inhibited concanavalin A (Con A) 5 micrograms.ml-1 and lipopolysaccharides (LPS) 10 micrograms.ml-1-induced splenocyte proliferation and phagocytic activity of activated peritoneal macrophages. Tri 10 mumol.L-1 reduced Con A-induced colony stimulating factor release from mouse splenocytes and LPS-challenged intracellular and extracellular interleukin-1 production from peritoneal macrophages. These results partially explain the wide and strong anti-inflammatory effects of Tri.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6030}
}