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Antitumor effect of alpha isomer of anordrin in vitro and cell cycle arrest at G1 phase

   
@article{APS6026,
	author = {Sheng-mei Weng and Yong-ping Xu and Bin Xu},
	title = {Antitumor effect of alpha isomer of anordrin in vitro and cell cycle arrest at G1 phase},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Alpha isomer of anordrin (2 alpha, 17 alpha-diethyl-A-norandrostane-2 beta, 17 beta-diol dipropionate, alpha-Ano) inhibited mouse hepatoma (Hep A) and P388 cell growth in vitro. alpha-Ano (20 micrograms.ml-1) inhibited the incorporation of [3H]uridine and [3H]thymidine into RNA and DNA within 3 h, but the inhibition of L-[3H]lysine incorporating into protein was not obvious. alpha-Ano had no effect on the DNA-dependent RNA synthesis with purified nuclei of Hep A cells. It is suggested that the inhibition of RNA and DNA syntheses is the major cause of the cytostatic effect. alpha-Ano blocked the P388 cells at G1/G0 phase, and the delay in G1/G0 to S phase transition plays an important role in the inhibition of P388 cell growth},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6026}
}