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Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord

  
@article{APS6025,
	author = {Miao Zhang and Ru-rong Ji and Yuan Fang and Ji-sheng Han},
	title = {Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Capsaicin (Cap) is a pharmacological tool to inactivate nociceptive afferents. The present study was undertaken to investigate the effects of topical application of Cap to sciatic nerve on the formalin-induced expression of proto-oncogene proteins c-fos in the rat spinal cord using immunohistochemical display of fos-like protein. In rats subjected to formalin injection into the hind paw, numerous fos-like immunoreactivity (FLI) neurons were found in the spinal dorsal horn, with heavy labeling in laminae I-II and V-VI. Following pretreatment of Cap, formalin-induced FLI expression was significantly abolished. It was suggested that activation of Cap-sensitive unmyelinated nociceptive afferents following formalin injection was primarily responsible for the activation of c-fos gene. Our data also provided further evidence supporting that topical application was an effective way to block the transmission of noxious primary afferents.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6025}
}