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Application of NONMEM method for evaluation of relative biological availability of ofloxacin

  
@article{APS6024,
	author = {Zhen Li and Zhang Chen and Hai-tong Zhuo},
	title = {Application of NONMEM method for evaluation of relative biological availability of ofloxacin},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The nonlinear mixed effect model (NONMEM) method for analysis of population pharmacokinetics, was applied to evaluate the relative biological availability of 2 ofloxacin (Ofl) products. The data of randomized crossover study of 2 kinds of Ofl tablets in 12 healthy volunteers were analyzed by NONMEM, as well as standard approach. The relative biological availability evaluated by NONMEM (F = 97.3 +/- 5.0%) was close to that by standard approach (F = 98.2 +/- 3.6%). NONMEM was also valid in accurately evaluating the relative biological availability using sparse clinical data (F = 91.7 +/- 8.0%) which could not be analyzed by standard approach. Thus, the usefulness and advantages of NONMEM were ascertained for the evaluation of biological availability using observational or experimental data},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6024}
}