@article{APS6022,
author = {Hong Chen and Ding-Feng Su and Tong-Hua Zhang and Hong-Jun Ding and You-Cai Yang and Si-Cong Chen},
title = {Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {1},
year = {2016},
keywords = {},
abstract = {The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg.kg-1. In reperfusion experiment, pretreatment with Sil 20 mg.kg-1 decreased significantly reperfusion-induced arrhythmia.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6022}
}