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Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits

   
@article{APS5997,
	author = {Cai-guo Huang and Zhong-lu Chu and Zhi-ming Yang},
	title = {Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Using radioimmunoassay, we found that berberine (0.50 mol.L-1) inhibited dose-dependently collagen-, ADP-, and arachidonic acid (AA)-induced TXA2 release from platelets. Berberine (25 mg.kg-1) iv lowered rabbit plasma level of PGI2 from 0.92 +/- 0.20 to 0.61 +/- 0.08 ng.ml-1 after 60 min. The results suggest that berberine inhibits AA release from cell membrane phospholipids and its metabolism.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5997}
}