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Effects of lobeline on slow action potential and force of contraction of guinea pig papillary muscle

   
@article{APS5995,
	author = {Ru-li Zhang and Shu-ben Tang},
	title = {Effects of lobeline on slow action potential and force of contraction of guinea pig papillary muscle},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Intracellular microelectrode techniques were used to study the effects of N1-receptor agonist lobeline on the slow action potentials (SAP) and the force of contraction (FC), induced by histamine, BaCl2 and aminophylline, in catecholamine-depleted guinea pig papillary muscles in the presence of an M-cholinergic receptor antagonist atropine (3 mumol.L-1). In these preparations lobeline (1-64 mumol.L-1) suppressed, in a dose-dependent manner, the action potential amplitude (APA), the action potential duration (APD), the maximal upstroke velocity (Vmax) and FC. Elevation of calcium concentration outside the myocardiac cells to 3.6 mmol.L-1 antagonized the effects of lobeline in different degrees. These results suggest that the lobeline inhibits the slow inward current Isi of myocardiac cells.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5995}
}