@article{APS5986,
author = {Qi-le Hu and Hong Wang and Yu-sheng Wang and Rong-xiu Chen and Wei-ming Shen and Ping Wang},
title = {Influences of Polyactin A on activities of human monocytes in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {6},
year = {2016},
keywords = {},
abstract = {Effects of Polyactin A (PAA) on abilities of human monocytes to synthesize and secrete interleukin-1 (IL-1) and to modulate natural killer (NK) cell activity in large granular lymphocytes (LGL) were investigated in vitro. Over a wide range of concentrations (0.01-100 micrograms.ml-1), PAA directly induced IL-1 synthesis and secretion, showing the maximal effect at 10 micrograms.ml-1, and evidently synergized with lipopolysaccharides (LPS) of E coli in stimulation of IL-1 production by human monocytes. The manifestation of PAA pretreated autologous monocytes in modulation of NK cell activity was closely related to PAA concentration. A boosting effect of PAA-treated monocytes on NK activity was observed when PAA 10-100 micrograms.ml-1 were used for pretreatment of monocytes, while an inhibitory influence of monocytes was found when PAA 0.01-0.1 microgram.ml-1 were used. These results demonstrate significant effects of PAA on functions of human monocytes, enhancing IL-1 production and affecting their regulative activity on NK cell cytotoxicity.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5986}
}