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Curve fitting taken maximum observed blood drug concentration as restricted condition for drug administered by non-vascular route

   
@article{APS5972,
	author = {Wen-gui Zhang},
	title = {Curve fitting taken maximum observed blood drug concentration as restricted condition for drug administered by non-vascular route},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {When using classical method to make curve fittings of blood drug concentration-time data for drugs administered by non-vascular route (for example, po or im), a considerable difference between maximal values of calculated and observed blood drug concentrations is often seen. The calculated value is often much lower than the observed one. In this paper, a least square method with restricted condition is suggested for solving this problem. Practical calculations confirm that this method solves the problem better.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5972}
}