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Electrophysiological effects of guan-fu base A on action potentials of guinea pig ventricular papillary muscles

   
@article{APS5969,
	author = {Li-ming Zhou and Ji-min Xu and Xiang-hua Chen and Yu-shui Xie},
	title = {Electrophysiological effects of guan-fu base A on action potentials of guinea pig ventricular papillary muscles},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Guan-fu base A (GA), an alkaloid first isolated in China, 50 mg.L-1 decreased the action potential amplitude and the maximal rate of depolarization (Vmax) of guinea pig papillary muscles in vitro. GA shortened the action potential period at 90% repolarization (APD90) without significant effect on the effective refractory period (ERP), resulting in an increased ERP/APD90 ratio. GA 50 mg.L-1 also slowed the conduction speed. The inhibiting effect of GA on Vmax showed frequency- and potential-dependent manners.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5969}
}