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Scavenging effects of dimercaptosuccinic acid per os on nickel in mice and rats

   
@article{APS5954,
	author = {Jian Xu and You-yi Liang and Jian-shi Zhang and Xue-ming Yan},
	title = {Scavenging effects of dimercaptosuccinic acid per os on nickel in mice and rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {In mice and rats given iv or im 63NiCl2 148-370 kBq, radioactivity was present in highest concentrations in kidney, lung, and liver. After given ig dimercaptosuccinic acid (DMSA) 1 g.kg-1, radioactivity decreased remarkably in kidney, lung, and blood. The excretion of 63Ni via urine and feces within 24 h, respectively 13.0 +/- 2.4% and 0.6 +/- 0.4%, was similar to that in the control group in mice. But radioactivity increased markedly in bone. The Ni content of bone decreased on d 7. In rats given im 63NiCl2 370 kBq, two different nickel complex peaks appeared in the gel chromatograms of serum, kidney, and lung. DMSA reduced the contents of protein-bound Ni in serum, kidney, and lung. The results showed that DMSA detoxified the Ni by forming a low toxicity Ni-DMSA complex to redistribute in the body.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5954}
}