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Transdermal permeability of l- and dl-norgestrel through human skin in vitro

   
@article{APS5953,
	author = {Guo-shen Chen and Sai-jun Gong and Rong-rong Zhou and Xian-ji Xie},
	title = {Transdermal permeability of l- and dl-norgestrel through human skin in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Transdermal permeability of l-norgestrel (l-NG) and dl-norgestrel (dl-NG) at 6 skin regions with and without stratum corneum was investigated by using Valia-Chien double-compartment permeation cells. The permeation rates and accumulative amounts within 72 h in vitro were measured by HPLC. The results showed that the permeation rates of dl-NG through intact skin were significantly higher than those of l-NG (P less than 0.01). For the skins without stratum corneum, the permeation rates and permeation amounts of l-NG and dl-NG were higher than those for the intact skin (P less than 0.01), but no significant difference was seen between l-NG and dl-NG. Hence the stratum corneum played an important role of rate-limiting barrier in the skin permeation of l-NG and dl-NG. It is possible that the difference in permeability between l-NG and dl-NG is related to their partition coefficients},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5953}
}