@article{APS5914,
author = {Lin-yong Xu and Yi-jing He and Wei Zhang and Sheng Deng and Qing Li and Wei-xia Zhang and Zhao-qian Liu and Dan Wang and Yuan-fei Huang and Hong-hao Zhou and Zhen-qiu Sun},
title = {Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {10},
year = {2016},
keywords = {},
abstract = {Aim: To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.
Methods: One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.
Results: The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.
Conclusion: The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5914}
}