@article{APS5846,
author = {Ji-qiang Chen and Nonifumi Yonehara and Yasuo Imai and Wen-jing Xu and Reizao Inoki},
title = {Effects of morphine on cutaneous blood flow and substance P release evoked by electric stimulation of rat sciatic nerve},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {4},
year = {2016},
keywords = {},
abstract = {Electric stimulation of the rat sciatic nerve containing sensory afferent fibers produced an increase in cutaneous blood flow. Morphine (10, 30 mumol.kg-1 ia infusion) inhibited the electric stimulation-induced increase of the cutaneous blood flow velocity, and its effect was antagonized by naloxone (2 mg.kg-1 ip). In order to investigate the cause of this effect, we determined immunoreactive substance P (iSP) levels in the sc perfusate of hind paw. We found that electric stimulation of the sciatic nerve led to a significant increase of iSP release into the sc perfusate. Morphine (30 mumol.kg-1 ia infusion) inhibited the electrical stimulation-induced release of iSP, and this effect was completely antagonized by naloxone (2 mg.kg-1 ip). These result suggest that morphine-induced inhibition of the electrical stimulation-evoked increase in cutaneous blood flow could result from inhibition of the release of SP from peripheral sensory nerve endings.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5846}
}