@article{APS5845,
author = {Chao-yu Miao and Feng-luan Zhang and Quan-ying Zhu and Ke-hong Zhang and Ding-feng Su},
title = {Effects of tetrandrine on hypertensive responses induced by electric stimulation and alpha-adrenoceptor agonists in pithed rats},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {4},
year = {2016},
keywords = {},
abstract = {Tetrandrine (Tet) 5 mg.kg-1 i.v. inhibited the pressor action of norepinephrine (NE) release induced by electric stimulation (10 V, 0.5-16 Hz) of spinal cord T11-L2. However, Tet 5 mg.kg-1 ia did not obviously attenuate the hypertensive responses to NE 0.51-16.91 micrograms.kg-1 i.v., indicating that Tet did not affect the alpha 1-adrenoceptors-mediated vasoconstriction. Tet 5 mg.kg-1 ia decreased the pressor responses to NE 0.05 and 0.17 micrograms.kg-1 i.v. and markedly reduced the dose-dependent hypertensive responses to B-HT920 i.v., a selective alpha 2-adrenoceptor agonist, proving that Tet reduced alpha 2-adrenoceptors-mediated vasoconstriction.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5845}
}