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Effects of adenosine and its derivatives on cultured myocardial cells and detection of adenosine receptors in rat

   
@article{APS5836,
	author = {Xiao-dong Wei and Shang-da Cai and Yi-guang Qiu and Shi-xiang You},
	title = {Effects of adenosine and its derivatives on cultured myocardial cells and detection of adenosine receptors in rat},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Adenosine and its derivatives 1 nmol.L-1 -0.1 mmol.L-1 elicited negative chronotropic effect on cultured rat myocardial cells. The respective IC50 were: L-PIA 85 +/- 10 greater than NECA 160 +/- 64 greater than adenosine 361 +/- 41 nmol.L-1. The negative chronotropic effect was antagonized by IBMX. [3H]Adenosine bound to myocardial cells of rat in a saturable way with a Kd of 238 nmol.L-1 and a Bmax of 7.6 pmol/10(8) cells. The binding of [3H]adenosine was competitively antagonized by adenosine, L-PIA, NECA, and IBMX. These results indicated the existence of adenosine receptor in rat myocardial cells.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5836}
}