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Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats

   
@article{APS5832,
	author = {You-ming Lu and Guo-qing Liu},
	title = {Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e by 48 +/- 5% in the infusion area and produced a characteristic abnormal EEG. l-Daurisoline dramatically prevented the reduction in (Ca2+)e, but not seizures (EEG). The results suggest that NMDA-operated calcium channels, but not NMDA-receptors, are involved in the effects of l-daurisoline on Ca2+ influx observed.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5832}
}