@article{APS5831,
author = {You-ming Lu and Jun-tian Zhang and Fu-qing Zhao and Fang Li},
title = {Effects of nimodipine on l-glutamate-induced seizures and Ca2+ influx in hippocampus in freely moving rats},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {4},
year = {2016},
keywords = {},
abstract = {Seizure (EEG) was studied in rats unilaterally injected in the dorsal hippocampus with l-glutamate (Glu). Extracellular Ca2+ content [(Ca2+)e] in the injected area was assessed by brain microdialysis coupled to automatic atomic absorption spectrophotometry. In this experimental epileptic model, an inhibition of Glu-stimulated epileptic activity and a fall in (Ca2+)e by nimodipine (Nim, 100 micrograms.kg-1) were seen. The spike- and wave-burst frequency was reduced from 30 to 5 bursts.min-1 (P less than 0.01, n = 8). Nim 25 and 50 micrograms.kg-1, without anticonvulsant activity, did not prevent the drop in (Ca2+)e. These results indicate that Nim exerts an antiepileptic effect on Glu-induced epilepsy. The mechanisms may be involved in blocking Ca2+ influx into neurons.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5831}
}