@article{APS5823,
author = {Zhen-wei Chu and Wei-cheng Wang and Yue-e Wang and Gen-di You and Zhi-ping Gu},
title = {Antifertility effect of the implant containing 16-methylene-17 alpha-acetoxy-19-norprogesterone (ST-1435)},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {3},
year = {2016},
keywords = {},
abstract = {The silastic capsules containing ST-1435 (0.5, 1, 2, 4, 6 or 8 mg) showed \"burst effect\" with a peak value of 4-15 micrograms.h-1 after incubation in vitro. A constant release rate was gradually approached within 1-2 wk. After the capsules were subcutaneous implanted or vaginally administrated, the rats manifested diestrus within 24-48 h. The normal estrus cycles and fertility were restored as soon as the release rate of implants decreased to 10 micrograms.d-1 in vitro. ST-1435 did not inhibit the superovulation induced by PMSG and HCG in immature female rats, but blocked the ovulation induced by LHRH in mature rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5823}
}