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Antifertility effect of the implant containing 16-methylene-17 alpha-acetoxy-19-norprogesterone (ST-1435)

  
@article{APS5823,
	author = {Zhen-wei Chu and Wei-cheng Wang and Yue-e Wang and Gen-di You and Zhi-ping Gu},
	title = {Antifertility effect of the implant containing 16-methylene-17 alpha-acetoxy-19-norprogesterone (ST-1435)},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The silastic capsules containing ST-1435 (0.5, 1, 2, 4, 6 or 8 mg) showed \"burst effect\" with a peak value of 4-15 micrograms.h-1 after incubation in vitro. A constant release rate was gradually approached within 1-2 wk. After the capsules were subcutaneous implanted or vaginally administrated, the rats manifested diestrus within 24-48 h. The normal estrus cycles and fertility were restored as soon as the release rate of implants decreased to 10 micrograms.d-1 in vitro. ST-1435 did not inhibit the superovulation induced by PMSG and HCG in immature female rats, but blocked the ovulation induced by LHRH in mature rats.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5823}
}