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Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein

   
@article{APS5816,
	author = {Guo-lin Zhang and De-zai Dai and Tao Xi and Xiao-dong Cong and Yun Zhang and Yin Dai},
	title = {Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein},
	journal = {Acta Pharmacologica Sinica},
	volume = {32},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate which endothelin receptors mediated isoproterenol (ISO)-induced downregulation of FKBP12.6/12 in cardiomyocytes and study whether argirhein, a novel compound containing rhein and L-arginine that has anti-inflammatory activity, could reverse the downregulation of FKBP12.6/12 induced by ISO.
Methods: Neonatal rat cardiomyocytes were incubated with ISO to downregulate FKBP12.6/12. Then the cells were treated with a selective ETA blocker (PD156707) and a ETB blocker (IRL1038), a dual ETA/ETB antagonist (CPU0213), and argirhein, respectively. FKBP12.6/12 expression was assayed by RT-PCR, Western blot, and immunocytochemistry.
Results: The expression of FKBP12.6 mRNA was reduced by 37.7% (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5816}
}