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Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells

   
@article{APS5811,
	author = {Guo-gan Zhong and Yan Jiang and Xue-qing Wang and Gang Yue},
	title = {Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Wistar rat myocardial cells were cultured. PDS 20-80 micrograms.ml-1; PTS 1.25-20 micrograms.ml-1 dose-dependently decreased their action potential parameters, indicating the possibility of being concerned in the blockage of Ca channel. After the free radical damage was induced by xanthine 0.42 mmol.L-1--xanthine oxidase 5.3 nmol.L-1 (X-XO). All the action potential parameters of the cardiac cells decreased without exception. Both PDA and PTS antagonized the electrical appearance of membrane damage induced by X-XO, suggesting that both PDS and PTS protect the myocardial cells from oxidative damage.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5811}
}