@article{APS5807,
author = {Rui-wu Zhang and Xi-can Tang and Yan-yi Han and Guo-wei Sang and Yang-da Zhang and Yong-xing Ma and Ci-lu Zhang and Ren-min Yang},
title = {Drug evaluation of huperzine A in the treatment of senile memory disorders},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {3},
year = {2016},
keywords = {},
abstract = {Huperzine A is an alkaloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It exhibits a significant anticholinesterase activity and has been used on myasthenia gravis patients. The therapeutic effects were studied by random, match and double-blind method on 56 patients of multi-infarct dementia or senile dementia and 104 patients of senile and presenile simple memory disorders. The curative effects were evaluated by Wechsler memory scale. The im dose for multi-infarct dementia was 0.05 mg bid for 4 wk, whereas that for senile and presenile simple memory disorders was 0.03 mg bid for 2 wk. Saline was used on control group. The result showed that the curative effect of huperzine A was significant. Only a few patients felt slight dizziness and this did not affect the therapeutic effects.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5807}
}