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Antagonistic effects of dextromethorphan on vasoconstriction of phencyclidine in vitro

   
@article{APS5804,
	author = {Wei-li Bao and Feng-yan Sun and Fu-chun Zheng and An-zhong Zhang},
	title = {Antagonistic effects of dextromethorphan on vasoconstriction of phencyclidine in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Bioassay and spectrophotofluorometry were used to study the antagonistic effect of dextromethorphan (DM) on phencyclidine (PCP) vasoconstriction in rabbit ear artery. DM (5 mumols.L-1) antagonized enhancement of PCP, N-[1-(2-thienyl) cyclohexyl] piperidine (TCP) and dizocilpine maleate (MK-801) (5 mumols.L-1) on electrical stimulation-induced vasoconstriction by 86 +/- 18%, 84 +/- 17%, and 86 +/- 18%, respectively (n = 6, P less than 0.01), but had no obvious bioactivity itself at the same concentration. DM (1, 2.5, and 5 mumols.L-1) inhibited the PCP effect and reduced the maximal effect of PCP with pD2' = 5.3 +/- 0.3 (n = 4). The contents of norepinephrine (NE) in control, PCP, and DM + PCP groups were 5 +/- 6, 12 +/- 8, and 5 +/- 6 ng.ml-1, respectively (n = 9). PCP (10 mumols.L-1) increased the NE release (P less than 0.05) but DM (10 mumols.L-1) inhibited it (P less than 0.01). The results suggest DM may be a noncompetitive blockader for PCP receptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5804}
}