@article{APS5767,
author = {Yuan HUANG and Shao-xuan FU and Yun-shan LI},
title = {Pharmacokinetics of m-nisoldipine in rabbits and rats},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {6},
year = {2016},
keywords = {},
abstract = {A reverse phase HPLC method was devised for determination of m-Nis in plasma. A mobile phase of methanol-KH2PO4 with a flow rate of 1 ml/min was used. Diazepam was used as the internal standard. A two-compartment model featured the pharmacokinetic process of m-Nis after its iv injection to rats (30 micrograms/kg) and rabbits (50 micrograms/kg). The pharmacokinetic parameters were: T 1/2 alpha = 4.3 min, T 1/2 beta = 63.6 min, Vd = 0.805 L/kg, Cl = 9 ml/(min.kg) in rats; T 1/2 alpha = 5.0 min, T 1/2 beta = 78.3 min, Vd = 1.191 L/kg, Cl = 11 ml/(min.kg) in rabbits. The pharmacokinetics for m-Nis after ig 200 micrograms/kg to rats described one-compartment model with parameters: T 1/2 = 84.8 min, Tmax = 31.2 min, Cmax = 49.97 micrograms/L, Vd = 0.792 L/kg and Cl = 25 ml/(min.kg).},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5767}
}