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Grey dynamic model of predicting the long-term effects of drugs and its application to pirenzepine

  
@article{APS5766,
	author = {Dong-ya ZHU and Shu-biao DING and Xiang-yu XU},
	title = {Grey dynamic model of predicting the long-term effects of drugs and its application to pirenzepine},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {In an attempt to approach the quantification of the dynamics of drug effects and the prediction of the long-term effects of drugs, a grey dynamic model was proposed and it was applied to predict the long-term effects of pirenzepine on pupils and peripheral leukocytes in dogs. The inconsiderable relative errors between the predicted and observed values suggest that the model-based equations for pupil diameter, neutrophils (%) and lymphocytes (%) which, obtained by fitting the data measured before and during initial 16 wk experiment, are acceptable for predicting the effects after 20- and 24-wk treatment with the drug.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5766}
}