@article{APS5734,
author = {Xiao-meng XU and Wen-de JIANG},
title = {Debrisoquine hydroxylation and sulfamethazine acetylation in a Chinese population},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {5},
year = {2016},
keywords = {},
abstract = {Both debrisoquine hydroxylation and sulfamethazine acetylation phenotypes were studied in the same native Chinese population. Debrisoquine hydroxylation status was determined by HPLC assay of debrisoquine metabolic ratio in urine after a single oral dose of 10 mg debrisoquine. Three poor metabolizers were found in 220 subjects (1.36%). One hundred and one subjects of this population previously debrisoquine phenotyped were also tested for acetylation phenotyping on a separate occasion. Their acetylation status were determined by HPLC assay of \"% acetylation\" after a single oral dose of 1 g sulfamethazine. Twenty (19.8%) slow acetylators were found. There were no significant association between the 2 metabolic pathways.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5734}
}