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Enhancing effect of protein kinase C activation on high K(+)-induced norepinephrine release

   
@article{APS5710,
	author = {Hua-yu Huang and Shu-ping Dai},
	title = {Enhancing effect of protein kinase C activation on high K(+)-induced norepinephrine release},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Raising the concentration of K+ in the superfusion medium increased the release of [3H]norepinephrine ([3H]NE) from rabbit hippocampus slices preincubated with [3H]NE. This evoked [3H]NE release was modulated by presynaptic alpha 2-adrenergic, presynaptic opioid kappa- and A1-adenosine receptors and augmented with increasing K+ concentration (20-120 mmol.L-1). The enhancement or inhibition of this release by activator (phorbol ester) or inhibitor (polymyxin B) of protein kinase C was blocked by tetrodotoxin and reduced with increasing K+ concentration. It was suggested that the Na(+)-influx was involved in the protein kinase C effect on the K(+)-evoked [3H]NE release.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5710}
}