@article{APS5699,
author = {Bao-qin Geng and Yau-kwan Ho and Robert G Hughes Jr and Thomas J Bardos},
title = {Inhibition of human cancer cell lines in vitro with mono- and polynucleotides containing 5-mercaptocytosine bases},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {2},
year = {2016},
keywords = {},
abstract = {Partially thiolated polycytidylic acid (5-mercaptopolycytidylic, MPC) and its double-stranded complex with polyinosinic acid [poly (I)].poly(I).MPC, were assayed in both antiproliferative and cytotoxicity tests against human cell lines: lung carcinoma A549, colon carcinoma HT-29, osteosarcoma HOS, and amnion cells (WISH). Inhibitory effects of MPC were noted in the antiproliferative assay with ID50 of 7, 24, 33, and 35 micrograms.ml-1, and in the cytotoxicity test with ID50 of 164, 174, 210, and 290 micrograms.ml-1 against the HOS, A549, HT-29, and WISH cells respectively. Comparison with the corresponding partially thiolated mononucleotide (5-mercapto-CMP + CMP) and the nucleoside (5-mercapto-cytidine) demonstrated that MPC was a more potent antiproliferative agent than either of its monomeric constituents. The inhibitory effect of MPC upon the incorporation of [3H]thymidine into the DNA of growing A549 cells paralleled its antiproliferative activity.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5699}
}