@article{APS5690,
author = {Song LI and Xue-yong ZHANG and Xi-tao CHEN and Su-yin ZHANG and Ling-ji CHEN and Jia-liu ZHANG},
title = {Selective cytotoxicity against human tumor cells by an anti-gastric cancer monoclonal antibody-mitomycin C conjugate},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {4},
year = {2016},
keywords = {},
abstract = {An anti-gastric cancer monoclonal antibody, MGb2, was chosen to prepare MGb2-mitomycin C (MMC) conjugate. Four to five molecules of MMC were introduced into each molecule of antibody with the antibody activity well retained. The conjugate showed a highly selective cytotoxicity upon human gastric cancer cells KATO-III. In the 48-h exposure test, the cytotoxic effect of MGb2-MMC upon target cells was similar to that of free MMC, but much greater than that of normal mouse immunoglobulin-MMC conjugate. Instead, the MGb2-MMC showed a statistically less cytotoxic effect upon non-target cells. Imaging and biodistribution studies indicated that the MGb2 was still well localized in tumor tissue after its conjugation with MMC.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5690}
}