@article{APS5684,
author = {Xiao-wen FU and Zi-wen QIAN and Jing-ru ZHANG},
title = {Effects of galanin on electrical activity of pancreatic islet cells},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {4},
year = {2016},
keywords = {},
abstract = {Intracellular microelectrode technique was used to investigate the effect of galanin on the electrical activity of beta cells of Langerhans islets of mice. Galanin 0.15 and 0.3 mumol/L in the perfusion medium inhibited the basic electrical activity induced by glucose 5.5, 11.1 and 20 mmol/L in decreasing the frequency and amplitude of the spikes. In some cells, during galanin inhibition there was a hyperpolarization after the spike. Verapamil (30, 60 and 90 mumol/L), a blocker of voltage-dependent Ca channels, blocked dose-dependently the electrical activity induced by glucose and attenuated the depolarization induced by KCl 50 mmol/L. Galanin 0.3 mumol/L also attenuated the depolarization induced by KCl 50 mmol/L, similar to the effect of verapamil. The results suggest that the effect of galanin on inhibition of the electrical activity of beta cell might be due to blocking of voltage-dependent Ca2+ channels.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5684}
}