@article{APS5670,
author = {Rui-hai AN and Rui-rong HE},
title = {Electrophysiological effects of m-nisoldipine and nisoldipine on papillary muscles of guinea pig},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {4},
year = {2016},
keywords = {},
abstract = {The effects of m-nisoldipine (m-Nis) and nisoldipine (Nis) on action potentials of papillary muscles in guinea pigs were studied using intracellular microelectrodes.
THE RESULTS:
(1) APD and Vmaxs in normal papillary muscles were reduced by m-Nis and Nis. However, the APA, Vmaxf and overshoot were not affected. (2) In the partially depolarized papillary muscles, the APA, overshoot, Vmax and APD were depressed in a dose-dependent manner. The inhibitory effects of Nis on APA, APD50 and PPD were greater than those of the m-Nis. (3) There was a good correlation between APD50 and PPD derived from a linear regression. By the linear equation, PPD was easily calculated from APD50.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5670}
}