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[3,4-Diaminopyridine and 4-aminopyridine evoked neurotransmitter release

   
@article{APS5657,
	author = {Hua-yu Huang and Shu-ping Dai},
	title = {[3,4-Diaminopyridine and 4-aminopyridine evoked neurotransmitter release},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {We used 3,4-diaminopyridine (3,4-DAP) and 4-aminopyridine (4-AP) as stimuli for evoking [3H]norepinephrine ([3H]NE) release in rabbit hippocampal slices to investigate the mechanism underlying the aminopyridines evoked [3H]NE release and the effect of protein kinase C activator phorbol ester PDB. 3,4-DAP and 4-AP evoked [3H]NE release were concentration dependent and enhanced by phorbol ester PDB. 4-AP (300 mumol.L-1) evoked [3H]NE release and enhancement of this evoked release by PDB were antagonized by protein kinase C inhibitor polymyxin B and almost abolished by tetrodotoxin. N-ethylmaleimide inhibited the facilitatory effect of PDB on 3,4-DAP evoked [3H]NE release implicating that G-protein is involved in the modulation of evoked [3H]NE release. 3,4-DAP evoked also dopamine release in caudate nucleus, and acetylcholine release in hippocampus suggesting that the mechanism by which 3,4-DAP evoked transmitters release is similar to that of electrical stimulation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5657}
}