How to cite item

Phencyclidine receptors in porcine cerebral arteries

   
@article{APS5613,
	author = {Yi-feng Lu and Feng-yan Sun and Ling-mei Zhang and An-zhong Zhang},
	title = {Phencyclidine receptors in porcine cerebral arteries},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {A specific, saturable, reversible, and selective binding site with Kd = 87 +/- 33 nmol/L, Bmax = 0.78 +/- 0.11 pmol/mg protein was detected in the binding of [3H] phencyclidine (PCP) to porcine cerebral blood vessels. Only ligands of PCP/sigma series were able to bind to the PCP receptors. [3H]PCP bound to its receptors was not displaced by etorphine or norepinephrine 0.1 mmol/L. A specific [3H]PCP binding site was found in porcine brain with Kd = 75 +/- 34 nmol/L, Bmax = 0.61 +/- 0.23 pmol/mg protein. Bioassay in vitro showed PCP enhanced the perfusion pressure of porcine cerebral blood vessels in a dose-dependent manner. This study provides direct evidence for PCP receptors on cerebral blood vessels, and suggests that PCP may produce cerebral vasospasm via PCP receptor interaction.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5613}
}