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Role of the epithelial sodium channel in salt-sensitive hypertension

   
@article{APS5541,
	author = {Yan Sun and Jia-ning Zhang and Dan Zhao and Qiu-shi Wang and Yu-chun Gu and He-ping Ma and Zhi-ren Zhang},
	title = {Role of the epithelial sodium channel in salt-sensitive hypertension},
	journal = {Acta Pharmacologica Sinica},
	volume = {32},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {The epithelial sodium channel (ENaC) is a heteromeric channel composed of three similar but distinct subunits, α, β and γ. This channel is an end-effector in the rennin-angiotensin-aldosterone system and resides in the apical plasma membrane of the renal cortical collecting ducts, where reabsorption of Na+ through ENaC is the final renal adjustment step for Na+ balance. Because of its regulation and function, the ENaC plays a critical role in modulating the homeostasis of Na+ and thus chronic blood pressure. The development of most forms of hypertension requires an increase in Na+ and water retention. The role of ENaC in developing high blood pressure is exemplified in the gain-of-function mutations in ENaC that cause Liddle's syndrome, a severe but rare form of inheritable hypertension. The evidence obtained from studies using animal models and in human patients indicates that improper Na+ retention by the kidney elevates blood pressure and induces salt-sensitive hypertension.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5541}
}