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Modulation of neuronal activity of locus coeruleus in rats induced by excitatory amino acids

   
@article{APS5468,
	author = {Han-xian PING and Hui-qiu WU and Guo-qing LIU},
	title = {Modulation of neuronal activity of locus coeruleus in rats induced by excitatory amino acids},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The excitatory actions on the unit activities of locus coeruleus induced by excitatory amino acids were studied. Quinolinic acid 10 nmol and N-methyl-D-aspartate (NMDA) 4 nmol icv markedly increased unit discharge of locus coeruleus neurons. The excitatory action was fully antagonized by icv 4 nmol D,L-2-amino-7-phosphonoheptanoic acid, a specific NMDA receptor antagonist. Excitatory effect induced by quinolinic acid is possibly mediated by excitatory amino acid receptors in locus coeruleus.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5468}
}