@article{APS5394,
author = {Ming-fa Zhang and Ya-qin Shen},
title = {Antidiarrheal and anti-inflammatory effects of berberine},
journal = {Acta Pharmacologica Sinica},
volume = {10},
number = {2},
year = {2016},
keywords = {},
abstract = {Berberine sulfate (Ber) 40 and 80 mg/kg ig reduced the purging effects of castor oil or Cassia angustifolia leaf in mice, but did not affect the gastrointestinal transport function of Chinese ink in normal mice. Ber 60 mg/kg ig significantly inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice. Ber 20 and 50 mg/kg sc markedly inhibited the increased vascular permeability induced by histamine 100 micrograms/0.1 ml ic in rats. Ber 4 and 8 mg/kg sc produced obvious inhibition in the xylene-induced swelling of mouse ear. The anti-inflammatory effects were enhanced in a dose-dependent manner. It is suggested that the antidiarrheal effect of Ber is relative to its restriction against exudative inflammation to a certain extent.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5394}
}