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Enhancement of absorption of tetramethylpyrazine by synthetic borneol

  
@article{APS5365,
	author = {Tie-feng CHEN and Shu-guang LIN and Lu-xi CHEN and Gui-fen JIANG and Zhao-yan LIANG and Ming YANG and Yi-zhi QIAN and Yan-ai XIE},
	title = {Enhancement of absorption of tetramethylpyrazine by synthetic borneol},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Sprague-Dawley rats were given ig tetramethylpyrazine phosphate (TMP) 5 mg/kg with or without previous borneol 5 mg/kg. The plasma TMP concentrations were analysed by GC method, and the data were treated by NONLIN program. The Cmax were 931 and 562 ng/ml, respectively, (P less than 0.01); while the AUC were 68,849 and 37,174, respectively, (P less than 0.05). It is suggested that the borneol enhances the absorption of the TMP but not in elimination.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5365}
}