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Inhibitory effects of ginsenoside Rg1 and Rb1 on rat brain microsomal Na+,K(+)-ATPase activity

   
@article{APS5354,
	author = {Jin CAO and Yu-qun ZHENG and Tian-pei LIU and Lu-zhong FENG},
	title = {Inhibitory effects of ginsenoside Rg1 and Rb1 on rat brain microsomal Na+,K(+)-ATPase activity},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Rat brain microsomal Na+, K(+)-ATPase activity was inhibited significantly and rapidly by ginsenoside Rb1. The IC50 of Rb1 for Na+,K(+)-ATPase was 6.3 +/- 1.0 mumol/L. The inhibition was enhanced with increasing the concentration of Rb1 or decreasing that of Na+ and K+. Kinetic analysis revealed that ginsenoside was an uncompetitive inhibitor with respect to ATP. The inhibitory effect of Rg1 on rat brain microsomal Na+,K(+)-ATPase was much weaker than that of Rb1.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5354}
}