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Effect of berberine on slow inward ionic current in guinea pig ventricular papillary muscle

  
@article{APS5349,
	author = {Xiao-dong Sun and Jin-ming Li and Li-jun Tian and Yu-ping Wang and Yan-feng Yu and Ke-yi Zhang},
	title = {Effect of berberine on slow inward ionic current in guinea pig ventricular papillary muscle},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Using a single sucrose gap voltage clamp technique, it was found that berberine hydrochloride (Ber-HCl) had a dose-dependent biphasic effect on Isi of guinea pig papillary muscle. It was more difficult to wash out the inhibitory effect of Ber-HCl on Isi. In the initial stage of the experiment, Ber-HCl 72 mumol/L and 365 mumol/L greatly improved the influx of extracellular Ca2+ and increased the amplitude of Isi. As the drug perfusion was prolonged, however, Ber-HCl dramatically blocked Ca2+ channels and decreased the influx of extracellular Ca2+ consequently, Isi was reduced in amplitude and later disappeared. This experiment further revealed the mechanisms of action of Ber on cardiac contractility and for the treatment of arrhythmias.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5349}
}