@article{APS5328,
author = {Yu-shu HUO and Shu-chen ZHANG and Dan ZHOU and Da-lin YAO and Geng-ye YOU and Hong-wei ZHANG and Shou-wu MA and Qi-zhong MO and Bin GONG and Ming-guang YI},
title = {Pharmacokinetics and tissue distribution of [3H]ginsenoside Rg1},
journal = {Acta Pharmacologica Sinica},
volume = {7},
number = {6},
year = {2016},
keywords = {},
abstract = {The pharmacokinetics of [3H]-Rg1, one of the main saponins of ginseng (Panax ginseng C A Meyer), was investigated in mice. The pattern of decline of the plasma level of [3H]Rg1 exhibited a three-compartment open model.
The pharmacokinetic parameters after ig: C=5.14986 exp (-0.0218318t)-exp (-2.22136t), Tmax=2.1 h, Cmax=489057 dpm, AUC=151 (after 48 h).
The pharmacokinetic parameters after iv: C=27.3023 exp (-9.98604t)+9.3115 exp (-0.79510t)+6.2085 exp (-0.02827t), K12=5.2/h, K13=1.2/h, K10=0.18/h, K21=4.0/h, K31=0.31/h, T1/2pi=0.069/h, T1/2alpha=0.87 h, T1/2beta=25 h, CL=1.2 L/h.kg, Vd=44 L/kg, AUC=311 (after 48 h), Vc=6.7 L/kg.
Tissue distribution of the drug: kidney>adrenal gland>liver>lung>spleen>pancreas>heart>testes>brain. The drug protein binding rates were 24+/-4% (plasma), 48+/-5% (liver), 22+/-4% (testes) and 8.0+/-0.6% (brain).},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5328}
}