@article{APS5317,
author = {Min-shi Zheng and Zong-yi Lu},
title = {Antiviral effect of mangiferin and isomangiferin on herpes simplex virus},
journal = {Acta Pharmacologica Sinica},
volume = {10},
number = {1},
year = {2016},
keywords = {},
abstract = {Using tissue culture techniques the present study assured us of the merits of mangiferin and isomangiferin in the antiviral action against HSV-1. Utilizing 4 main patterns for evaluating drug effectiveness (ie intratube drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by logarithm determination of HSV-I inhibition that isomangiferin was superior to such control drugs as acyclovir, idoxuridine, and cyclocytidine in logarithm by 0.27-0.50, and that mangiferin was lower than isomangiferin in logarithm by 0.53. The average plaque reduction rates of mangiferin and isomangiferin were 69.5% and 56.8%, respectively. All in all, the antiviral effect of mangiferin and isomangiferin was attributed presumably to their capability to inhibit virus replication within cells.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5317}
}