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A stimulation study on characteristics in a steady-state for Michaelis-Menten elimination kinetics

  
@article{APS5316,
	author = {Huai-wu ZHOU and Rong-rong JING and Zu-qiang QIU},
	title = {A stimulation study on characteristics in a steady-state for Michaelis-Menten elimination kinetics},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Using the pharmacokinetic parameters of phenytoin reported in literature, we have studied the characteristics in a steady-state for Michaelis-Menten elimination kinetics following multiple does of a drug in 128 hypothetical casas through computer simulation. We verified the formulas about average plasma concentration at the steady-state, the time to reach steady-state, and bioavailability proposed in previous article. We obtained the empirical formulas to estimate average plasma concentration or maximal plasma concentration in a steady-state from minimal plasma steady-state concentration for the phenytoin.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5316}
}